No. The integration instructions for SearchResults are the same if you're using a single file design or a data-separated design. Just be sure to do all this work in your interface file.
If you have multiple interface files you can place the search widget (the field you type criteria into and buttons associated with that) in each of your different interface files. Each of these files will also require the beginning of the search script (everything before the comment "Begin Search by Loading Settings") but the remainder of the search script should be in the interface file in which you have pasted the fmSearchResults layouts.